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Neural expression of Lov protein in the Drosophila embryo (Beckingham)

One of the most important challenges in biology is to understand how the nervous system works. Several labs within the Department of Biochemistry and Cell Biology are actively studying this issue with a variety of experimental techniques and systems. Experimental systems in use include the model systems yeast, Drosophila, zebrafish, nematodes, chick, and mouse. The experimental techniques in use, which include biochemical, genetic, behavioral, electrophysiological, anatomical and computational techniques, are being used to answer a wide range of questions in neuroscience. This wide range of methodologies, experimental systems, and experimental questions provides a unique environment for research into the structure, function and development of the nervous system.

Regulation of neuronal activity in Drosophila melanogaster (Stern Lab)

Faculty links:
Kathleen M. Beckingham:  Calcium signaling in Drosophila; gravitational sensing in Drosophila.    

Peter Lwigale :  Molecular regulation of corneal development; Neural crest differentiation, corneal innervation and avascularity; fetal wound regeneration (lab home page).

James A. McNew:  Molecular mechanism of biological membrane fusion; membrane protein expression and reconstitution, intracellular vesicular transport; functional reconstitution of exocytosis; role of SNARE proteins in yeast sporulation and cytokinesis; analysis of cell-cell fusion (lab home page).   
Michael Stern:  Roles of the hereditary spastic paraplegia genes, particular atlastin, in regulating Drosophila motor neuron function and locomotor behavior. Regulation of growth of Drosophila larval peripheral nerves by neuron-glia and glia-glia intercellular signalling.

Weiwei Zhong :  Using the nematode C. elegans as a model to decipher gene interaction networks regulating development and behavior (lab home page).

Exposure and survival of embryos at different stages of development from the Lwigale Lab